Synthesis of Hexamine Ligands by Using Trityl as an N-Blocking Group
- 1 September 1997
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 27 (18) , 3145-3150
- https://doi.org/10.1080/00397919708004172
Abstract
The amino-groups of diethylenetriamine were regioselectively protected by trityl groups and then reacted with dihalogenated alkylane to give the terminal N-blocked hexamine derivatives, from which a series of hexamine ligands (5 a-f) were obtained by removing the trityl groups with 5.0 M HCl solution. Alternatively, the hexamine ligands could be also prepared via amidation and reduction reactions. The synthetic routes described here are mild, efficient and easy to handle.Keywords
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