ENHANCEMENT BY DISULFIRAM (ANTABUSE) OF TOXIC EFFECTS OF 95 TO 97-PERCENT O-Z ON THE RAT LUNG

  • 1 January 1979
    • journal article
    • research article
    • Vol. 208  (3) , 377-380
Abstract
Disulfiram (Antabuse), a drug used in alcohol aversion therapy, has been demonstrated to protect various species against hyperbaric O2 toxicity. Disulfiram accelerates the onset of pulmonary edema and death of rats exposed to normobaric 95-97% O2. When rats were given 200 mg of disulfiram per kg body weight [b.wt.], 100% of the rats died at 24-48 h of O2 exposure whereas only 5% of the rats died when exposed to O2 without disulfiram. This effect was not seen with an equal dose of diethyldithiocarbamate, the reduced monomer of disulfiram. The toxic effect was not due to an inhibition of superoxide dismutase, nor did disulfiram significantly affect the level of glutathione or change the reduced to oxidized glutathione ratio in the lung. Concurrent administration of 200 mg per kg b.wt. of ascorbate, vitamin E or reduced glutathione or 100 mg/kg of catalase did not affect the toxic response.