EFFECTS OF METHAQUALONE ON TEMPERATURE REGULATION OF MICE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 17  (1) , 41-52
Abstract
Methaqualone [sedative-hypnotic which is frequently abused] produced dose and time dependent changes in the rectal temperature of mice. More specifically, the drug produced poikilothermia. This effect appeared to be produced by methaqualone itself rather than a liver metabolite since SKF525A [2-diethylaminoethyl2,2-diphenylvalerate hydrochloride], a compound known to block drug metabolizing enzymes in the liver, did not abolish the phenomemon. Tolerance to the temperature altering effects of methaqualone was also shown.

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