Modification of blood pressure and nictitating membrane response to sympathetic amines by selective monoamine oxidase inhibitors, types A and B, in the cat

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Abstract
1 The selective monoamine oxidase (MAO) inhibitors clorgyline, selegiline and AGN 1135 did not cause a change in responses of the cat nictitating membrane to preganglionic sympathetic nerve stimulation at 5 Hz. 2 Both selective MAO-A and MAO-B inhibitors markedly potentiated nictitating membrane contractions in response to β-phenylethylamine (PEA). However, the responses to tyramine were unchanged. 3 The pressor responses to tyramine were potentiated by the selective MAO-A inhibitor clorgyline (2 mg kg−1) but not by selegiline (1.0 mg kg−1) and AGN 1135 (1.5 mg kg−1), selective MAO-B inhibitors. 4 At the doses used selegiline and AGN 1135 caused a near total selective inhibition of liver and brain MAO-B, while clorgyline inhibited MAO-A only in the brain. 5 AGN 1135, like selegiline, could be a useful drug in potentiating the action of L-DOPA in Parkinson's disease.