Effect of Synthetic Pantothenic Acid on Adrenal Hemorrhage, Atrophy, and Necrosis in Rats

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Abstract
Albino rats (48) were placed at weaning on a B-complex deficient diet with supplements of thiamin, pyridoxine (B6), riboflavin, nicotinic acid, and choline. After 6-10 wks. some of the rats were given 6 to 14 daily doses of 100 [gamma] of synthetic pantothenic acid; this was followed by definite improvement in the symptoms of nosebleed, sticky exudate on the eyelids, "spectacled eyes," and depilation about the nose and mouth. 10 of 16 untreated animals had hemorrhage, necrosis, or atrophy of the adrenal glands or a combination of these lesions; 14 showed marked fat depletion of the adrenals. Only one adrenal of one rat of 28 littermates given synthetic pantothenic acid had hemorrhage, atrophy, or necrosis and only 4 showed even moderate fat depletion of the adrenals. A deficiency of pantothenic acid is at least one of the causes of adrenal hemorrhage, necrosis, and atrophy in rats on deficient diets.
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