−1 Frameshifting at a CGA AAG Hexanucleotide Site Is Required for Transposition of Insertion Sequence IS 1222
Open Access
- 15 May 2004
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 186 (10) , 3274-3277
- https://doi.org/10.1128/jb.186.10.3274-3277.2004
Abstract
The discovery of programmed −1 frameshifting at the hexanucleotide shift site CGA_AAG, in addition to the classical X_XXY_YYZ heptanucleotide shift sequences, prompted a search for instances among eubacterial insertion sequence elements. IS 1222 has a CGA_AAG shift site. A genetic analysis revealed that frameshifting at this site is required for transposition.Keywords
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