Rhodium-Catalyzed Reductive Aldol Reactions Using Aldehydes as the Stoichiometric Reductants
- 1 December 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (51) , 18012-18013
- https://doi.org/10.1021/ja056130v
Abstract
Chelated acyl rhodium hydrides, generated from the addition of [Rh(dppe)]ClO4 to β-sulfide-substituted aldehydes, can function as the stoichiometric reductants in reductive aldol processes. Unsaturated nitriles, esters, and ketones can be used as enolate equivalents, and a variety of simple α- and β-substituted aldehydes can be employed. The use of a second, more electrophilic, aldehyde allows three-component reactions to be performed.Keywords
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