Clinical Trial in Patients with Diabetes Mellitus of an Insulin-like Compound Obtained from Plant Source

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Abstract
Clinical study of an insulin-like compound obtained from vegetable source (vegetable insulin) was carried out on 9 patients with diabetes mellitus. The active hypoglycemic principle, purified protein extract, was obtained from fruits and from tissue cultures of the plant Momordica charantia. This extract was homologous to insulin obtained from animal pancreas. It showed a consistent hypoglycemic effect in patients with diabetes mellitus. The average fall in blood sugar level at the peak effect of vegetable insulin apparently statistically significant. Onset of action was within 30-60 min with the peak effect 6 h after administration of the dose of plant insulin. No hypersensitivity reaction to this extract was observed in the group of patients studied.

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