Direct Copper‐Free Domino Conjugate Addition‐Cycloallylation using Organozinc Reagents
- 7 July 2008
- journal article
- research article
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 350 (10) , 1569-1576
- https://doi.org/10.1002/adsc.200800242
Abstract
The Direct Approach: Enones possessing appendant allylic carbonates react directly with diorganozinc reagents in the presence of zinc diiodide [ZnI2] to provide 5‐ and 6‐membered ring products of tandem or domino conjugate addition‐cycloallylation in good to excellent yield. In a related copper‐free transformation, allylic carbonates are found to engage in direct allylic substitution with diorganozinc reagents.Keywords
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