LARGE VESSEL OCCLUSION AND GANGRENE IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND LUPUS-LIKE DISEASE - A REPORT OF 6 CASES

  • 1 August 1986
    • journal article
    • research article
    • Vol. 13  (4) , 740-747
Abstract
Six patients are presented, all of whom had systemic lupus erythematosus or a "lupus-like" disease and who developed major thromboses with gangrene of the extremities. Four of the 6 patients had circulating antiphospholipid antibodies at some point during the course of their illness. These serological markers, which have been associated with a tendency to thromobosis, may have contributed to the development of gangrene in these patients. Histological examination of affected arteries in 4 patients did not show any evidence of vasculitis. One patient in whom antiphospholipid antibodies were negative showed healing vasculitis on histology.