A STEREOCONTROLLED SYNTHESIS OF 2-METHYL-2-ALKENENITRILES FROM C-METHYL-C,N-BIS(TRIMETHYLSILYL)KETENIMINE AND ALDEHYDES
- 5 January 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 12 (1) , 97-100
- https://doi.org/10.1246/cl.1983.97
Abstract
A stereocontrolled synthesis of 2-methyl-2-alkenenitriles is achieved via the diastereoselective aldol type reaction of C-methyl-C,N-bis(trimethylsilyl)ketenimine with aldehydes in the presence of a mixture of TiCl4 and Ti(O-iPr)4.Keywords
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