INFLUENCE OF THYROXINE ON PROTEIN METABOLISM

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Abstract
Experiments are reported on the influence of thyroxine on N-excretion in force-fed rats kept on a constant food intake. Thyroidec-tomy in the rat is followed by an increased output of urinary N. This is a late effect not to be interpreted as unspecific postoperative negative N. balance (alarm reaction). Small, physiological doses of thyroxine decrease N-excretion in the thyroidec-tomized rat (protein anabolic effect.) In the intact rat such doses of thyroxine have no influence on N-balance. Large amts. of thyroxine increase N-excretion both in the intact and in the thyroidec-tomized rat (protein catabolic effect.) In the hypophysectomized rat small doses of thyroxine fail to exert a protein-analbolic effect and large doses fail to exert a protein-catabolic effect.