Serotonin Metabolism in Pellagra
- 1 October 1975
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 32 (10) , 708-710
- https://doi.org/10.1001/archneur.1975.00490520078015
Abstract
• Altered mental status is common in pellagrins. We evaluated the mental status of pellagrins in relation to the neurohormone, serotonin or 5-hydroxytryptamine (5-HT). Levels of 5-hydroxyindoleacetic acid (5-HIAA), an end product of serotonin in the urine and cerebrospinal fluid (CSF), and of platelet 5-HT were determined in a group of pellagrins and in normal subjects. The results indicated that the 5-HT concentration was reduced in platelets and 5-HIAA excretion in urine was below normal levels. The 5-HIAA concentration in CSF was also reduced, suggesting a decrease in 5-HT functional activity in the brain.Keywords
This publication has 7 references indexed in Scilit:
- Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan LevelsScience, 1971
- Mental changes and platelet serotonin in pellagrinsClinica Chimica Acta; International Journal of Clinical Chemistry, 1970
- Fluorimetric determination of 5-hydroxyindoleacetic acid in human urine and cerebrospinal fluidClinica Chimica Acta; International Journal of Clinical Chemistry, 1969
- POSSIBLE ROLE FOR DIETARY LEUCINE IN THE PATHOGENESIS OF PELLAGRAThe Lancet, 1969
- Electroencephalographic patterns in pellagraElectroencephalography and Clinical Neurophysiology, 1968
- Serotonin Depletion by Dietary LeucineNature, 1965
- The effect of the oral administration of leucine on the metabolism of tryptophanBiochemical Journal, 1963