Reproductive Loss: How Much is Preventable?

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Abstract
IN this issue Wramsby et al.1 describe chromosomal analysis of 23 human preovulatory oocytes and suggest that as many as half may have had an abnormal karyotype. This is an example of how the analysis of early human embryonic development is becoming accessible through changes in obstetric practice. Those interested in the extent and causes of human embryonic loss have long been frustrated by the existence of a "black box," the period between conception and clinically recognized pregnancy (usually about four to five weeks after fertilization) during which study has been impossible. All discussions of this topic must still refer . . .