Disposition of Methylprednisolone and Its Sodium Succinate Prodrug In Vivo and in Perfused Liver of Rats: Nonlinear and Sequential First-Pass Elimination
- 1 May 1991
- journal article
- research article
- Published by Elsevier in Journal of Pharmaceutical Sciences
- Vol. 80 (5) , 409-415
- https://doi.org/10.1002/jps.2600800502
Abstract
No abstract availableKeywords
This publication has 16 references indexed in Scilit:
- Simultaneous analysis of methylprednisolone hemisuccinate, cortisol and methylprednisolone by normal-phase high-performance liquid chromatography in human plasmaJournal of Chromatography B: Biomedical Sciences and Applications, 1988
- Mean Residence Time Concepts for Pharmacokinetic Systems with Nonlinear Drug Elimination Described by the Michaelis–Menten EquationPharmaceutical Research, 1988
- Receptor-mediated pharmacodynamics of prednisolone in the ratJournal of Pharmacokinetics and Biopharmaceutics, 1986
- Pharmacokinetics of Methylprednisolone, Methylprednisolone Sodium Succinate, and Methylprednisolone Acetate in DogsJournal of Pharmaceutical Sciences, 1986
- A review of metabolite kineticsJournal of Pharmacokinetics and Biopharmaceutics, 1985
- LAGRAN program for area and moments in pharmacokinetic analysisComputer Programs in Biomedicine, 1983
- Characterization of steroid hormone ester hydrolyzing enzymes in liver microsomesBiochemical Pharmacology, 1981
- Sequential first-pass elimination of a metabolite derived from a precursorJournal of Pharmacokinetics and Biopharmaceutics, 1979
- Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearanceJournal of Pharmacokinetics and Biopharmaceutics, 1977
- Simultaneous measurement of cardiac output and its distribution with microspheres in the ratCardiovascular Research, 1976