Toxic Variability and Radiation Sensitization by Dichlorodiammineplatinum(II) Complexes in Salmonella typhimurium Cells
- 1 September 1984
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 99 (3) , 596-608
- https://doi.org/10.2307/3576334
Abstract
The oxidative coordination compound cis-dichlorodiammineplatinum(II) (cis-DDP) is again shown to be a hypoxic cell radiation sensitizer. The mechanism of cis-DDP-induced radiation sensitization is complex. Results here indicate that cis-DDP sensitization operates in part through reactive free radicals, in part through the interactions of radiation-induced reactive Pt(I) intermediates, and in part through the involvement of thermodynamic and kinetic aspects of Pt(II)-DNA binding during irradiation. For the 1st time, radiation sensitization by trans-DDP is compared with a sensitizing concentration of cis-DDP within the same study. Both analogs are sensitizers, but with significant differences. Irradiated hypoxic solutions of cis-DDP are found to be more toxic than unirradiated solutions. [The use of cis-DDP as an antitumor drug is discussed.].This publication has 17 references indexed in Scilit:
- ACETYLORNITHINASE OF ESCHERICHIA COLI: PARTIAL PURIFICATION AND SOME PROPERTIESPublished by Elsevier ,2021
- Binding ofcis- andtrans-Dichlorodiammineplatinum(II) to DNA: Evidence for Unwinding and Shortening of the Double HelixScience, 1979
- DNA-PROTEIN AND DNA INTERSTRAND CROSS-LINKING BY CIS-PLATINUM(II) AND TRANS-PLATINUM(II) DIAMMINEDICHLORIDE IN L1210 MOUSE LEUKEMIA-CELLS AND RELATION TO CYTOTOXICITY1979
- Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium.Proceedings of the National Academy of Sciences, 1978
- Quantitative forward mutation assay in Salmonella typhimurium using 8-azaguanine resistance as a genetic marker.Proceedings of the National Academy of Sciences, 1978
- Radiation-Induced DNA Damage and Lethality in E. coli As Modified by the Antitumor Agent cis-Dichlorodiammineplatinum(II)Radiation Research, 1977
- Relative efficiencies of a series of square-planar platinum(II) compounds on Salmonella mutagenesisMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1977
- Radiation Sensitization of Bacterial Spores by cis-Dichlorodiammineplatinum(II)Radiation Research, 1976
- Electron-Affinic Sensitization: VII. A Correlation between Structures, One-Electron Reduction Potentials, and Efficiencies of Nitroimidazoles as Hypoxic Cell RadiosensitizersRadiation Research, 1976
- Platinum complexes: A new class of antineoplastic agentsJournal of Pharmaceutical Sciences, 1976