The Enzyme of Granulocytes That Produces Superoxide and Peroxide

Publisher Website
Google Scholar
Abstract
Since 1933, it has been known that granulocytes display a substantial increase in oxygen consumption during phagocytosis.1 This oxygen uptake has been linked to several metabolic changes in phagocytizing cells2 and results in the generation of a variety of agents relevant to the killing of bacteria, fungi, mycoplasmas, viruses and tumor cells (reviewed recently in references 3 and 4). For about the past 50 years, a great deal of research has focused on attempts to elucidate the enzymologic basis of this respiratory phenomenon. The quest for truth in this field has become a rather contorted history over the years, characterized . . .