ADDITIVE AND SYNERGISTIC EFFECTS OF A NOVEL ANTIESTROGEN, TOREMIFENE (FC-1157A), AND HUMAN INTERFERONS ON ESTROGEN RESPONSIVE MCF-7 CELLS-INVITRO

  • 1 January 1985
    • journal article
    • research article
    • Vol. 63  (4) , 187-190
Abstract
The effect of human interferons alpha and gamma alone and in combination with a novel antiestrogen toremifene were studied in vitro using MCF-7 cell line, an estrogen receptor positive and antiestrogen sensitive cell line. The effects were evaluated by a simple bioluminescence method with which the number of living cells was obtained as cellular adenosine triphosphate (ATP) content. The growth of MCF-7 cells was inhibited both by interferon alpha and interferon gamma. At least additive effect was evident when the cells were exposed to combination of interferons and toremifene: the combination was additive with interferon gamma + toremifene and synergistic with interferon alpha + toremifene. The combination of toremifene and interferons may have clinical importance.