Free radical scavenging: a potentially beneficial action of thiol-containing angiotensin converting enzyme inhibitors
- 1 December 1990
- journal article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 18 (6) , 1184-1185
- https://doi.org/10.1042/bst0181184
Abstract
Summary Free radical (FR) scavenging may be a therapeutically useful adjunctive property of angiotensin converting enzyme (ACE) inhibitors. In this study we have shown that SH-containing ACE inhibitors (captopril, epicaptopril, zofenopril) are potent FR scavengers at a concentration of 4 × 10-5 m whereas non-SH ACE inhibitors (enalaprilat, quinaprilat and perindoprilat) have no FR-scavenging activity at this concentration. Furthermore, the SH-containing agents preferentially scavenged general radicals rather than superoxide radicals, i.e. suggesting that these drugs would be effective in quenching the culprit FR in ischaemia/reperfusion injury.Keywords
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