Treatment of Bacterial Endocarditis with Cephalothin

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Abstract
Ten patients with bacterial endocarditis were treated with cephalothin. Nine (Streptococcus viridans, four, microaerophilic streptococcus, two, anaerobic streptococcus, one, and Staphylococcus aureus, two) appeared cured when studied six months to four years after therapy ended. The tenth (Staph. albus) had negative blood cultures at the time of death. In seven, bacterial strains were available for testing, and growth was inhibited by a 30-μg cephalothin disk. In two other patients with enterococcal endocarditis, no serum bactericidal activity was demonstrated in vitro after administration of cephalothin in combination with streptomycin.