The effect of food and metoclopramide on the pharmacokinetics and side effects of bromocriptine
- 1 July 1991
- journal article
- clinical trial
- Published by Springer Nature in European Journal of Drug Metabolism and Pharmacokinetics
- Vol. 16 (3) , 177-181
- https://doi.org/10.1007/bf03189956
Abstract
The effect of food and metoclopramide on the pharmacokinetics of bromocriptine was investigated in 7 healthy subjects. Plasma concentrations of bromocriptine were measured by radioimmunoassay after a single oral dose of 7.5 mg bromocriptine. Maximal plasma concentrations of bromocriptine were slightly lower when the drug was given after breakfast Bioavailability of the drug was not significantly reduced by food nor by metoclopramide pre-treatment Side effects of bromocriptine were considerably reduced by metoclopramide pre-treatment (0.5 mg/kg); the decrease was about 83% as estimated from Table II.Keywords
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