Gamma-Beta Thalassemia: A Cause of Hemolytic Disease of the Newborn

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Abstract
A full-term female infant had hemolytic hypochromic anemia at birth. Blood morphology was consistent with thalassemia. Neither hemoglobin H nor hemoglobin Barts was detected. Studies of globin-chain synthesis in peripheral blood revealed a deficiency of synthesis of gamma and beta chains in relation to alpha-chain synthesis. As the infant matured, her peripheral smear morphology improved and became indistinguishable from that of her father and six other relatives who had beta thalassemia proved by measurement of globin-chain synthesis. Gamma-beta thalassemia is therefore an evanescent disease that may be severe during the normal period of dependence on gamma-chain synthesis.

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