Homologous Sex-Linked Mutations in Man and Other Mammals

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Abstract
It is pointed out that the sex-linked, congenital hypotrichosis with anadontia of cattle, studied in France by Drieux et al., is apparently identical with the sex-linked abnormality in man known as anhidrosis with anadontia, or anidrotic ectodermal dysplasia. Since it had been shown earlier that there is a sex-linked hemophilia in the dog which is physiologically indistinguishable from the sex-linked hemophilia of man, there are now known 2 mutations in the human sex chromosome for which corresponding and apparently homologous mutations have been identified in the sex chromosomes of other mammals. Discussion of the significance of this fact is postponed pending the discovery of additional cases, and it is suggested that these might be found by search in laboratory animals for mutations known to be sex-linked in man.

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