ON THE RELATIONSHIP BETWEEN THE VIABILITY OF BACTERIA DAMAGED BY ANTISEPTICS AND THEIR RESPONSIVENESS TO MODIFICATIONS OF THE COUNTING MEDIUM

Publisher Website
Google Scholar
Abstract
SUMMARY: Counts of phenol treated Escherichia coli and of Pseudomonas aeruginosa exposed to phenylmercuric nitrate varied with the medium, and the differences were greater when the mortality of the suspension was higher. The regression of the logarithm of the response (the count on a modified medium divided by the count on the control) on the logarithm of the viable count on the control was linear. This relationship is shown to occur when the log survivor‐time curves from one suspension under two different conditions are divergent. To compare responses from different trials, dose reduction factors may be used or a correction may be made for the mortality level. Alternatively the mortality level should be controlled.