Actions of hemicholinium and triethylcholine on responses of guinea-pig colon to stimulation of autonomic nerves

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Abstract
Hemicholinium caused a failure of responses of the guinea-pig colon to stimulation of extrinsic parasympathetic and sympathetic nerves: failure of the parasympathetic responses occurred the more readily. In seven of 20 experiments, hemicholinium did not block the inhibitory response to sympathetic nerve stimulation but the latent period between the start of a train of stimuli and the first sign of relaxation was prolonged after repeated stimulation in the presence of hemicholinium in all 20 experiments. Triethylcholine caused failure of responses of the guinea-pig colon and a reduction of responses of rabbit ileum to sympathetic nerve stimulation. Choline sometimes reversed the blocking action of hemicholinium on responses to parasympathetic and sympathetic nerve stimulation.