Possible association between CTLA4 DNA polymorphisms and early onset type 1 diabetes in a UK population
- 1 June 2001
- journal article
- research article
- Published by Springer Nature in Genes & Immunity
- Vol. 2 (4) , 233-235
- https://doi.org/10.1038/sj.gene.6363749
Abstract
Linkage and association has been reported between CTLA4 DNA markers and susceptibility to type 1 diabetes in some populations, but not others. We performed case-control and family-based association studies to assess if the CTLA4 A49G and intron 1 C/T polymorphisms were associated with development of early onset type 1 diabetes in the Northern Ireland population. The distribution of A49G and C/T alleles in cases (n = 144) was similar to those observed in controls (n = 307). In contrast, significant distortions in allele transmissions from informative parents to probands were observed for both the A49G (P = 0.02) and C/T (P = 0.01) polymorphisms employing 297 nuclear families. Our results suggest that the CTLA4 gene may play a minor role in the overall genetic predisposition to type 1 diabetes in this UK population.Keywords
This publication has 20 references indexed in Scilit:
- Rising incidence of insulin dependent diabetes in children aged under 5 years in the Oxford region: time trend analysisBMJ, 1997
- Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groupsHuman Molecular Genetics, 1997
- The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes RegistryHuman Molecular Genetics, 1996
- Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8Human Molecular Genetics, 1996
- The HLA Associated Predisposition to Type 1 Diabetes and Other Autoimmune DiseasesJournal of Pediatric Endocrinology and Metabolism, 1996
- A Comparison of Linkage Disequilibrium Measures for Fine-Scale MappingGenomics, 1995
- T-cell activation: integration of signals from the antigen receptor and costimulatory moleculesImmunology Today, 1995
- Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locusNature Genetics, 1995
- The Pathogenesis of Insulin-Dependent Diabetes MellitusNew England Journal of Medicine, 1994
- A genome-wide search for human type 1 diabetes susceptibility genesNature, 1994