Treponema denticolaIs Resistant to Human β-Defensins
Open Access
- 1 July 2002
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 70 (7) , 3982-3984
- https://doi.org/10.1128/iai.70.7.3982-3984.2002
Abstract
Spirochetes, includingTreponema denticola, are implicated in the pathogenesis of periodontal disease. BecauseT. denticolalacks lipopolysaccharides that serve as targets for human β-defensin (hβD) binding, we postulated thatT. denticolawould resist killing by hβD. We showed thatT. denticolais resistant to hβD-1 and -2. Protease inhibitors did not enhance killing ofT. denticolaby hβD-2, suggesting that degradation of hβD-2 by treponemal proteases is not a major factor inT. denticolaresistance.Keywords
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