Fatal CMV pneumonia associated with steroid therapy after autologous transplantation in patients previously treated with fludarabine
- 1 March 1998
- journal article
- case report
- Published by Springer Nature in Bone Marrow Transplantation
- Vol. 21 (6) , 619-621
- https://doi.org/10.1038/sj.bmt.1701126
Abstract
Fludarabine has been associated with an increased risk of opportunistic infections, possibly related to the induction of profound CD4+ lymphopenia. We observed two cases of cytomegalovirus pneumonia (CMV-IP) in a total of nine patients over a 5-year period who had previously received fludarabine and who proceeded to autografting. Both patients also received steroids post-transplant. CMV-IP was observed in one of 104 other autograft recipients over this time who had not received prior fludarabine. This observation suggests that the combination of fludarabine pre-transplant and steroids post-transplant may increase the risk of invasive CMV disease in autograft recipients.Keywords
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