Parathyroid Hormone–Related Protein as a Regulator of pRb and the Cell Cycle in Arterial Smooth Muscle
- 13 July 2004
- journal article
- Published by Wolters Kluwer Health in Circulation
- Vol. 110 (2) , 177-185
- https://doi.org/10.1161/01.cir.0000134483.30849.b7
Abstract
Background— Parathyroid hormone–related protein (PTHrP), a normal product of arterial vascular smooth muscle (VSM), contains a nuclear localization signal (NLS) and at least 2 translational initiation sites, one that generates a conventional signal peptide and one that disrupts the signal peptide. These unusual features allow PTHrP either to be secreted in a paracrine/autocrine fashion, and thereby to inhibit arterial smooth muscle proliferation, or to be retained within the cytosol and to translocate into the nucleus, thereby serving as an intracrine stimulator of smooth muscle proliferation.Keywords
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