Interaction between class B β‐lactamases and suicide substrates of active‐site serine β‐lactamases
- 29 January 1999
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 443 (2) , 109-111
- https://doi.org/10.1016/s0014-5793(98)01689-5
Abstract
The most widely used inactivators of active-site serine β-lactamases behave as substrates of four class B metallo-β-lactamases, but the efficiency of the catalytic process can vary by several orders of magnitude. A comparison of the kinetic parameters for the α and β isomers of 6-iodopenicillanic acid shows that there is no general preference for the α isomer and that the efficient hydrolysis of imipenem by these enzymes must rest on other factors.Keywords
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