Factor VII: its Turnover Rate and its Possible Role in Thrombogenesis
- 1 January 1960
- journal article
- research article
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 04 (02) , 196-200
- https://doi.org/10.1055/s-0038-1654496
Abstract
The range of the hourly turnover rate of factor VII, found in 17 normal individuals, 14 patients with thrombo-embolic diseases and 3 patients with congential hypoproconvertinaemia, was 11.1—16.6% of the total body pool of factor VII (mean normal value 13.8%). The possible significance of this rapid turnover rate of factor VII in prophylactic anticoagulant treatment with 4-hydroxycoumarin derivatives is stressed. * This investigation was supported by the Netherlands Organization for Applied Scientific Research (T.N.O.).Keywords
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