Efficacy of Nitrendipine as Baseline Antihypertensive Therapy

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Abstract
Summary To determine whether calcium antagonists might be used alternatively to β-blockers in antihypertensive therapy, we investigated if monotherapy with oxprenolol (160–320 mg/day) and nitrendipine (20–40 mg/day) were equally effective on clinical casual blood pressure (BP), ambulatory BP monitoring (Remler), and BP during mental challenge (video game). In a prospective randomized long-term study, 60 white male civil servants (mean ± SD = 43 ± 6 years) with mild essential hypertension only were treated for at least 4 months. Average BP before therapy was 149 ± 11/97 ± 11 mm Hg. The antihypertensive effect was not different between the two groups (19/14 versus 21/12 mm Hg). Both groups did not differ in BP at rest, in BP during mental challenge (141 ± 7/109 ± 5 versus 146 ± 9/112 ± 8 mm Hg, NS), and average ambulatory BP monitoring at work (122 ± 12/81 ± 17 versus 132 ± 14/79 ± 17 mmHg, NS), which was identical with the clinical casual BP. Thus, nitrendipine can effectively be used in long-term baseline antihypertensive monotherapy.

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