STUDY ON THE ABSORPTION OF KETOPROFEN TOPICALLY ADMINISTERED IN MAN - COMPARISON BETWEEN TISSUE AND PLASMA-LEVELS

  • 1 January 1986
    • journal article
    • research article
    • Vol. 6  (1) , 69-72
Abstract
In this study the transcutaneous passage of ketoprofen (gel) topically administered and its distribution in the inner part of the knee-joint were evaluated in six patients. The ketoprofen concentrations detected were: 4.70 mcg/g .+-. 3.87 in the intra-articular adipose tissue; 2.35 mcg/g .+-. 2.41 in the capsular sample and 1.31 mcg/g .+-. 0.89 in the synovial fluid. Plasma concentrations of the drug were also examined. In the samples studied, the ketoprofen levels amounted to about one hundred times higher than the plasma concentrations.

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