Development of a von Willebrand-Like Syndrome after Prolonged Use of Hydroxyethyl Starch
Open Access
- 1 November 1987
- journal article
- case report
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 88 (5) , 653-655
- https://doi.org/10.1093/ajcp/88.5.653
Abstract
A 29-year-old female with no prior history of bleeding tendencies had gingival bleeding develop after 10 days of treatment with hydroxyethyl starch (HES), 1,000 mL/day. Laboratory studies revealed a marked reduction in Factor VIII coagulant activity (VIII:C), von Willebrand’s factor antigen (vWF:Agn), and (VIII R:RCo), resembling severe type I von Willebrand’s disease. The HES was stopped and the bleeding subsided. The levels of Factor VIII:C, vWF:Agn, and Factor VIII R:RCo gradually increased to normal over the following 17 days.Keywords
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