Contributions to the cytological effects of medicinal plants. I. The mitodepressive effects of water extracts of Boerhaavia diffusa and Vernonia amygdalina on Allium cepa root tip mitosis.

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Abstract
This work has demonstrated that water extracts of the two medicinal plants, Boerhaavia diffusa (Fam. Nytaginaceae) and Vernonia amygdalina (Fam. Compositae) contain active substances which are mitodepressive in Allium cepa. The major observable effects are decrease in the number of dividing cells and changes in chromosome structure leading to stickiness. Higher concentrations of the extract from V. amygdalina lead to nuclear disintegration and cell death and this is believed to be due to the presence of the sesquiterpene lactones, vernodalin and vernomygdin.

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