Interferon Treatment of Human Stomach and Breast Carcinoma Xenografts in Nude Mice

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Abstract
Comparative effects of natural and recombinant interferons (IFNs)-α and -β on xenografted human gastric and breast carcinoma lines in nude mice were studied. The lines were sensitive to IFNs. The breast carcinoma lines were more sensitive than the gastric carcinoma lines to IFNs. Natural IFN-β was more effective than the other three IFNs on the gastric carcinoma lines. One breast carcinoma line was more sensitive to IFN-α whereas the other was more sensitive to IFN-β. Large doses and frequent injections of IFNs were necessary for optimal effectiveness.