Synthesis of conjugates ofL-fucose andortho-carborane as potential agents for boron neutron capture therapy
- 1 August 2002
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 80 (8) , 943-948
- https://doi.org/10.1139/v02-054
Abstract
The synthesis of three potential boron neutron capture therapy agents (6–8) is reported. The compounds synthesized are comprised of ortho-carborane covalently attached to L-fucose via C-6. Incorporation of the carborane moiety was achieved either through the reaction of an L-fucose-derived alkyne with decaborane or by the coupling of a 6-amino-L-galactopyranose derivative with carborane carboxylic acid chloride (18).Key words: L-fucose, fucosyltransferase, boron neutron capture therapy, ortho-carborane.Keywords
This publication has 20 references indexed in Scilit:
- Carboranyl Bisglycosides for the Treatment of Cancer by Boron Neutron Capture TherapyChemBioChem, 2001
- Fucose in N-glycans: from plant to manBiochimica et Biophysica Acta (BBA) - General Subjects, 1999
- The α1-6-fucosyltransferase gene and its biological significanceBiochimica et Biophysica Acta (BBA) - General Subjects, 1999
- Synthesis of 5-(Carboranylalkylmercapto)-2‘-deoxyuridines and 3-(Carboranylalkyl)thymidines and Their Evaluation as Substrates for Human Thymidine Kinases 1 and 2Journal of Medicinal Chemistry, 1999
- Rapid Conversion of Unprotected Galactose Analogs to their Udp-Derivatives For Use in the Chemo-Enzymatic Synthesis of Unnatural OligosaccharidesJournal of Carbohydrate Chemistry, 1998
- An Aminated GDP-Fucose Analog Useful in the Fucosyltransferase Catalyzed Addition of Biological Probes onto Oligosaccharide Chains1Journal of Carbohydrate Chemistry, 1995
- The Role of Chemistry in the Development of Boron Neutron Capture Therapy of CancerAngewandte Chemie International Edition in English, 1993
- Solution-phase segment synthesis of boron-rich peptidesThe Journal of Organic Chemistry, 1993
- Hydrophilically augmented glycosyl carborane derivatives for incorporation in antibody conjugation reagentsOrganometallics, 1988
- Synthesis of angiotensins, bradykinins and substance P octapeptides in which the residues Phe and Tyr have been replaced with car and of [Car1, Leu5]‐enkephalinHelvetica Chimica Acta, 1979