OESTRIOL-3-GLUCOSIDURONATE, A MAJOR URINARY METABOLITE OF OESTRIOL AND OESTRIOL-16(17?)-GLUCOSIDURONATE

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Abstract
Estriol-16-Cl4 (OE3-16-C14) was administered to a non-pregnant woman and estriol-16-Cl4-16(17?)-glucosiduronate (OE3-16-C14-16(17?)G1) to a pregnant woman and the urinary estriol conjugates were isolated and identified. More than 85% of the radioactive material administered to the two subjects was excreted in the urine within 96 hours. In both cases more than 16% of the administered radioactive material was isolated and identified as estriol-16-Cl4-3-glucosiduronate (OE3-16-C14-3G1) and more than 70% as OE3-16-C14-16(17?)G1. Estriol-3-glucosiduronate is a major urinary metabolite of both oestriol and estriol-16(17?)-glucosiduronate.

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