A Predictable Pathophysiological Model of Porcine Hepatic Failure
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in European Surgical Research
- Vol. 18 (5) , 283-292
- https://doi.org/10.1159/000128537
Abstract
A technique is described in which acute hepatic failure may be uniformly induced in pigs using a combination of oral phenobarbitone pretreatment and 2-hour interruption of hepatic arterial blood supply followed by intragastric carbon tetrachloride. This results in deep hepatic coma over a narrowly predictable time span and death within 12–52 h. Amino acid levels in plasma and cerebrospinal fluid obtained 24 h after the induction of hepatic failure were similar to those reported in human and experimental encephalopathy.Keywords
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