Crystal Structures of Synthetic Analgetics. V. Dextromoramide.
- 1 January 1976
- journal article
- research article
- Published by Danish Chemical Society in Acta Chemica Scandinavica
- Vol. 30b (2) , 95-100
- https://doi.org/10.3891/acta.chem.scand.30b-0095
Abstract
The molecular and crystal structure of dextromoramide was determined by X-ray methods. The crystals are orthorhombic, space group P212121 with unit cell dimensions a = 9.720(4) .ANG.; b = 12.226(3) .ANG.; c = 18.381(3) .ANG.. The structure was determined by direct methods and the model refined to an R-value of 0.036 for 1788 observed reflections. The mean e.s.d.''s in bond lengths and angles are 0.004 .ANG. and 0.3.degree., respectively. The morpholine moiety is nearly in anti position relative to the quaternary C atom C6, the pertinent angle C6-C7-C9-N2 being -159.4.degree.. The pyrrolidine ring has the envelope conformation and the amide group is strictly planar. The conformations of some acyclic analgetics are discussed.Keywords
This publication has 2 references indexed in Scilit:
- Stereochemical Factors and Receptor Interactions Associated with Narcotic AnalgesicsJournal of Pharmaceutical Sciences, 1966
- Synthetic Analgesics: Stereochemical ConsiderationsJournal of Pharmacy and Pharmacology, 1954