DYSKERATOSIS FOLLICULARIS (DARIER'S DISEASE)

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Abstract
Dyskeratosis follicularis has been studied by numerous observers. The ultimate conception of the process, however, has not altered from that proposed by Darier, after he forsook the theory of an infectious etiology. The present conception is that it is a dyskeratosis characterized by a proliferation in the prickle cell layer associated with a disturbance in keratinization. Some observers, particularly Hamdi1 and Brunauer,2 have emphasized the proliferation of the basal cell layer. The particular features in this disorder are the corps ronds and grains, which Darier first considered to be infectious elements, probably psorosperms. These are now thought by some observers to be evidence of hyaline degeneration. Between the proliferated basal cells and the malpighian layer is frequently seen a hiatus or lacuna which may contain isolated degenerated malpighian elements and sometimes contains the corps ronds and grains. Hamdi studied the formation of the lacunae and expressed the belief

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