Influence of an essential fatty acid deficient diet on absorption of topical hydrocortisone in the rat
- 1 November 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 117 (5) , 607-615
- https://doi.org/10.1111/j.1365-2133.1987.tb07493.x
Abstract
Using a rat dermatosis model, produced by dietary essential fatty acid deficiency (EFAD), which is characterized by histological changes and elevated transepidermal water loss, changes in skin permeability were studied using [14C]‐hydrocortisone (HC). Skin, serum and urinary levels of HC were measured, and absorption and excretion of HC in EFAD rats compared with that in control rats on a normal diet. This animal model has demonstrated the importance of the functional integrity of the horny layer in skin penetration.This publication has 17 references indexed in Scilit:
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