Alterations of the Glycolytic Pathway and Adenine Nucleotide State in Livers of Clofibrate Treated Rats
- 1 January 1977
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 9 (02) , 132-136
- https://doi.org/10.1055/s-0028-1093561
Abstract
The influence of Clofibrate on the glycolytic pathway in liver was studied. The changes in the activity of glucokinase and hexokinase were not significant. A reduction of phosphofructokinase (p < 0.05) and pyruvate kinase activity was found (p < 0.0005) during Clofibrate feeding. An in vitro inhibition of these enzymes could not be demonstrated by Clofibrate up to a concentration of 2.5 mM. Crossover plots of glycolytic intermediates indicate that the reduced pyruvate kinase activity may influence the glycolytic pathway in vivo. Clofibrate feeding induces a lower ATP:ADP ratio, a lower adenylate energy charge and elevates AMP levels in rat liver. This may possibly stimulate the hepatic glycogenolysis and the glucose utilisation by this organ.Keywords
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