A proton magnetic resonance nuclear Overhauser enhancement study. Application to vitamin D derivatives D2 and D3
- 15 June 1980
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 58 (12) , 1206-1210
- https://doi.org/10.1139/v80-188
Abstract
Nuclear Overhauser effect [nOe] difference experiments on vitamins D2 and D3 at 400 MHz allow an unambiguous assignment for the HE and HZ protons bonded to the C-19 carbon. This assignment is especially important since the A ring, and hence the C-19 atom, undergoes a conformational interconversion. The importance of proton nOe difference experiments in determining points of configuration indicate that the assignment of resonances based on allylic coupling constants in a molecule undergoing a conformational equilibrium can be incorrect.Keywords
This publication has 3 references indexed in Scilit:
- A high field proton magnetic resonance study of the solution conformation of thromboxane B2Canadian Journal of Chemistry, 1980
- The solution conformation of prostacyclin as determined by high field proton magnetic resonance techniquesCanadian Journal of Chemistry, 1980
- Intramolecular proton nuclear Overhauser effect study of the solution conformation of valinomycin in dimethyl sulfoxideBiochemistry, 1976