Reduction of steroid 17-ketones by enantiomeric chiral reducing agents

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Abstract
The reduction of steroid 17-ketones by a chiral hydrosilane–rhodium–(–)(2S,3S)-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane reagent allows greater stereoselectivity of 17α-alcohol formation than is obtained by other methods.