ANALYSIS OF MILK SECRETED SPONTANEOUSLY BY VIRGIN RATS BEARING INDUCED MAMMARY TUMOURS

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Abstract
SUMMARY Biochemical and immunological studies were performed on milk secreted spontaneously by 1-yr-old virgin female Sprague—Dawley rats. They had received 30 mg 9,10-dimethyl-1,2-benzanthracene when 50 days old and most had mammary gland tumours. No milk secretion was found specifically in any of these tumours. The fat content of the secretion was twice that of post-partum milk and slight differences were demonstrated in the saturated fatty acid composition. The protein concentration was doubled but both casein and milk plasma proteins were identical to those of post-partum milk. The lactose concentration was one quarter that of post-partum milk but similar milk specific carbohydrates were present. Lactate dehydrogenase isoenzymes were quantitatively similar in each. It was shown that the secretion by virgin rats closely resembled post-partum milk.

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