The incorporation of 65Zn in mammary tumours and some other tissues of mice after injection of the isotope

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Abstract
Distribution of Zn65 in mice with spontaneously occurring mammary tumors and in non-tumor-bearing mice was studied at various intervals after a single intraperitoneal injection of a Zn65-containing zinc-glycine complex. The tumor tissue had a small but statistically significant higher Zn65 content (mg tissue N) than had "normal" (apparently non-malignant) mammary gland tissue of the same mouse at 1, 3, 7 and 14 days, but not at 3 hours, after injection of Zn65. Mean tumor values 1, 3 and 7 days after the injection were about twice those for normal mammary gland tissue. "Normal" mammary gland tissue from injected tumor-bearing mice generally contained a little less Zn65 than did the corresponding tissue from non-tumor mice, but the difference was not statistically significant. The Zn65 contents of the blood, liver, kidney, lung and skin of the tumor-bearing mice were not statistically different from corresponding values obtained with normal mice.