ALDOSTERONE METABOLISM IN LIVER DISEASE

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Abstract
Aldosterone secretion rates were measured as pH 1 extractable conjugates and as a glucuronide in 6 patients with hepatic cirrhosis using 16-H3 aldosterone. On unrestricted diets the aldosterone secretion rates were 19, 85 and 94 [mu]g/ day in 3 patients with ascites and edema, and 140, 170 and 386 [mu]g/day in 3 patients without fluid retention. When 5 of these patients were kept on a low Na diet at least a week, slight increases in secretion occurred, but these were lower than previously noted in normal subjects. A great variation was noted in the proportion of radioactivity excreted as pH 1 conjugates evidenced by a range of 6-25.2% of the initial dose excreted on 5 different occasions by an individual.

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