Hormones and growth factors in the pathogenesis of spinal ligament ossification
Open Access
- 11 April 2007
- journal article
- review article
- Published by Springer Nature in European Spine Journal
- Vol. 16 (8) , 1075-1084
- https://doi.org/10.1007/s00586-007-0356-4
Abstract
Ossification of the spinal ligaments (OSL) is a pathologic condition that causes ectopic bone formation and subsequently results in various degrees of neurological deficit, but the etiology of OSL remains almost unknown. Some systemic hormones, such as 1,25-dihydroxyvitamin D, parathyroid hormone (PTH), insulin and leptin, and local growth factors, such as transforming growth factor-β (TGF-β), and bone morphogenetic protein (BMP), have been studied and are thought to be involved in the initiation and development of OSL. This review article summarizes these studies, delineates the possible mechanisms, and puts forward doubts and new questions. The related findings from studies of genes and target cells in the ligament of OSL are also discussed. Although these findings may be helpful in understanding the pathogenesis of OSL, much more research needs to be conducted in order to investigate the nature of OSL.Keywords
This publication has 99 references indexed in Scilit:
- A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spineHuman Genetics, 2006
- Factors Affecting Prognosis of Patients Who Underwent Corpectomy and Fusion for Treatment of Cervical Ossification of the Posterior Longitudinal LigamentJournal of Spinal Disorders & Techniques, 2005
- An immunohistochemical evaluation of extracellular matrix components in the spinal posterior longitudinal ligament and intervertebral disc of the tiptoe walking mouseJournal of Orthopaedic Science, 2004
- Glucose-induced fibronectin and collagen type III expression in renal fibroblasts can occur independent of TGF-β1Kidney International, 2003
- Activation and localization of cartilage-derived morphogenetic protein-1 at the site of ossification of the ligamentum flavumEuropean Spine Journal, 2001
- Ossification of the Posterior Longitudinal Ligament in Vitamin D-Resistant RicketsSpine, 2001
- Activation of nuclear factor κB at the onset of ossification of the spinal ligamentsJournal of Orthopaedic Science, 2000
- Hyperleptinemia in Female Patients with Ossification of Spinal LigamentsBiochemical and Biophysical Research Communications, 2000
- Localization of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) during Human Embryonic Development: High Affinity Binding to Basement MembranesBiochemical and Biophysical Research Communications, 1994
- Extraspinal Tendon and Ligament Calcification Associated with Long-Term Therapy with EtretinateNew England Journal of Medicine, 1986