THE EFFECT OF PROLONGED ADMINISTRATION OF ESTROGEN

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Abstract
Gardner, Allen, Smith and Strong1succeeded in producing in mice a large carcinoma of the cervix with metastases in the lumbar lymphatic glands by treating the animals for 319 days with 10,500 international units of estradiol benzoate. This tumor could be successfully transplanted to male and female mice of the same strain and in this strain it developed rapidly without any further treatment with estrogen. Even previously some authors had reported certain individual cases in which the administration of estrogen had produced cervical carcinomas in mice.2As a matter of fact, we cannot draw conclusions concerning the human subject from results obtained in mice, but just the same the knowledge of the experimental production of carcinoma of the uterus by the use of estrogen, even if this has happened but rarely, must alarm the clinician; and all the more so since similar results have been obtained in monkeys.

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